Mitochondrial function assessed by P MRS and BOLD MRI in non-obese type 2 diabetic rats
نویسندگان
چکیده
1 Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 2 Case Center for Imaging Research, Case Western Reserve University, Cleveland, Ohio 3 Department of Electrical and Computer Engineering and Biomedical Engineering Institute, Old Dominion University, Norfolk, Virginia 4 Department of Radiology, Case Western Reserve University, Cleveland, Ohio 5 Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio
منابع مشابه
Mitochondrial function assessed by 31P MRS and BOLD MRI in non‐obese type 2 diabetic rats
The study aims to characterize age-associated changes in skeletal muscle bioenergetics by evaluating the response to ischemia-reperfusion in the skeletal muscle of the Goto-Kakizaki (GK) rats, a rat model of non-obese type 2 diabetes (T2D). (31)P magnetic resonance spectroscopy (MRS) and blood oxygen level-dependent (BOLD) MRI was performed on the hindlimb of young (12 weeks) and adult (20 week...
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Figure 2. Higher Pi signal corresponded to lower oxygen utilization (lower absolute change) for control group, whereas the diabetes group, with more oxygen utilization, had smaller Pi signal change. 7125 Characterization of Metabolic Response to Ischemia in Skeletal Muscle of Non-obese Early Stage Type 2 Diabetic Rats by in vivo 31P MRS and BOLD MRI Yuchi Liu, Xunbai Mei, Nicola Lai, and Xin Yu...
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